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Table 1 Hazardous effects of formaldehyde [2, 4, 6, 16, 25]

From: Concentration and formation behavior of naturally occurring formaldehyde in foods

Interactions Possible health hazards
Ingestion Excessive ingestion can cause
 Severe pain with inflammation, ulceration and necrosis of the mucous membranes lining almost every internal organ
 Nausea
 Vomiting blood
 Diarrhea with bloody stool
 Blood from urine
 Gastrointestinal lesions
 Acidosis
 Vertigo and circulation failure
 Systemic effects include
 Metabolic acidosis
 CNS depression and coma
 Respiratory distress
 Renal failure
 Liver failure
 Cancer and tumor development and
 Irreversible neurotoxicity
Inhalation The Department of Health and Human Services (DHHS) and the International Agency for Research on Cancer (IARC) have characterized formaldehyde as a human carcinogen based on studies of inhalation exposure in humans and laboratory animals. Formaldehyde has been linked to
 Nasopharyngeal cancer
 Gastrointestinal cancer and
 Possible links to brain cancer and leukemia
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